Effect of Vehicle on Drug Release Profiles of Time-Controlled Release Granule Containing Metominostrobin
Shigeru TASHIMA, Shinji SHIMADA, Iwao ANDO, Kohei MATSUMOTO, Reiji TAKEDA and Tomonori SHIRAISHI
J. Pestic. Sci.
25, 128-132 (2000)
We examined the effect of talc as an vehicle on release profile of time-controlled release granule (TCRG). In this report, TCRG was prepared by coating a water insoluble polymer to the pre-coated granule which consists of a powder blend containing active ingredient, swelling agent and talc. The lag time of metominostrobin release from TCRG was prolonged with increase of talc, a hydrophobic vehicle. We discussed the mechanism in this phenomenon. 1Studies on Controlled Release Granule Applied into Seedling Box (Part.3)
