Synthesis and Selective Bioactivity of New Pyrazolecarboxamide Derivatives
Tokio OBATA, Katsutoshi FUJII, Eisuke FUNAKI, Kiyoshi TSUTSUMIUTI, Akira OHOKA Shin SUIZU and Yuh KANETSUKI
J. Pestic. Sci.
24, 33-37 (1999)
New types of acaricides containing pyrazolecarboxamide as a core structure were synthesized and their acaricidal potency and fish toxicity were examined. N-Phenoxyethylpyrazole-5-carboxamide derivatives (III) showed remarkably a high activity against two-spotted spider mite and severe toxicity against fish such as medaka. On the other hand, among N-acyl-N-phenoxyethylpyrazole-5-carboxamide derivatives (IV) which were designed to get the selective activity between mite and fish, the only series of compounds having tert-butyl group at 3-position and hydrogen atom at 4-position on the pyrazole ring showed much less toxicity against medaka with higher activity against mites than the corresponding unacylated compounds. Their structure-activlty relationships are discussed in this paper.
