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Synthesis and Fungicidal Activitiesof [2-(2,5-Dimethylphenoxymethyl)-a-methoxyiminobenzyl]-isoxazole Derivatives
Hiroyuki KAI, Tsuneo ICHIBA, Nobuo MIKI Akira TAKASE and Michio MASUKO
J. Pestic. Sci.
24, 130-137 (1999)
A series of [2-(2,5-dimethylphenoxymethyl)-a-methoxyiminobenzyl]isoxazole derivatives were synthesized and their fungicidal activities against crop diseases were assessed. Our studies of the structure activity relationships revealed the fungicidal activities against cucumber powdery mildew and wheat powdery mildew were the strongest when the isoxazole moiety was comprised of 4,5-dihydro-3-isoxazolyl, 3-isoxazolyl and 3-methyl-5-isoxazolyl groups. Of the two geometrical isomers at the oxime moiety, the E-isomers of non-substituted isoxazole derivatives were more active than the Z-isomers. On the other hand, the Z-isomers of methyl-substituted isoxazole derivatives were more active than the E-isomers Further, [2-(2,5-dimethylphenoxymethyl)-a-methoxyiminobenzyl]isoxazole derivatives exhibited highly potent respiratory inhibition.
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