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Synthesis and Insecticidal Activity of [1(2H),2'-Bipyridin]-2-one Derivatives
Noriyasu SAKAMOTO, Takao ISHIWATARI and Noritada MATSUO
J. Pestic. Sci.
25, 373-378 (2000)
A series of [1(2H),2'-bipyridin]-2-one derivatives were synthesized and their insecticidal activity against German cockroaches and houseflies was evaluated. The strength of activity varied markedly depending upon the substituents and their positions on the pyridone and the pyridine ring. Electron-withdrawing substituents at the 3, 3', 5 and 5'-positions on both rings are required for the insecticidal activity, especially against German cockroaches. Furthermore, a couple of trifluoromethyl groups at the 5 and 5'- positions on both rings are essential for the activity. Among all compounds tested, a chlorine atom at the 3-position on the pyridone ring, and a chlorine atom, a fluorine atom or a trifluoromethyl group at the 3'-position on the pyridine ring were more preferable.
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