|
|
Partition of 2,4-Dichlorophenoxyacetic Acid Derivatives in Phosphatidylcholine Multi-lamellar Vesicles
Toshiyuki KATAGI
J. Pestic. Sci.
26, 354-360 (2001)
The interaction of 2,4-dichlorophenoxyacetic acid (2,4-D) with multi-lamellar vesicles of dimyristoyl and dipalmitoyl L-y-phosphatidylcholine was examined from the pH dependency of partition and pH- and temperature-dependent polarization of fluorescence probes such as 1,6-diphenyl-1,3,5-hexatriene. It was strongly suggested that 2,4-D in the undissociated form was located at the region from the neighborhood of the glycerol backbone to a shallow site of the hydrophobic core of the lipid bilayers and that its anionic species was adsorbed at the membrane surface. Fluorescence study with the derivatives of 2,4-D showed that hydrophobicity and pKa of these acids determined their interaction with membrane.
|
