Fungicidal Activities of alpha-Methoxyphenylacetic Acid Derivatives
Tsuneo ICHIBA, Takami MURASHI, Toshikazu OHTSUKA and Michio MASUKO<
J. Pestic. Sci.
27, 118-126 (2002)
A number of alpha-alkoxyphenylacetic acid derivatives were synthesized and their fungicidal activities were examined. Studies of structure-activity relationships revealed strong fungicidal activity when the substituent at the alpha-position was a methoxy group and a substituted phenoxymethyl group was introduced to the 2-position of the benzene ring of the phenylacetic acid moiety. When a substituted phenoxy group was introduced to this position, the fungicidal activity was very weak. It was also shown that N-methyl-phenylacetamide derivatives had stronger activities than phenylacetic acid methyl ester derivatives. Among the compounds synthesized in this study, 2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2-methyl-N-methylacetamide (35) showed the most potent fungicidal activity against a wide range of crop diseases.
