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Synthesis of a New 1,2,4-Oxadiazol-5-one Derivative, KC10017, and Its Controlling Activity against Rice Blast Disease Caused by Magnaporthe grisea
Heung Tae KIM, Ji Young MIN, Gyung Ja CHOI, Jin-Cheol KIM, Byung Sup KIM, Young Ryun CHUNG, Bum Tae KIM, Young Sup KIM, Isamu YAMAGUCHI and Kwang Yun CHO
J. Pestic. Sci.
27, 229-234 (2002)
Fungicidal characteristics of KC10017, an oxadiazole compound, were investigated in a greenhouse. KC10017 showed strong protective activity against rice blast. When KC10017 (0.5 ¥õe/ml solution) was sprayed on leaves, rice blast was controlled almost completely. Its protective activity decreased temporally, reaching 54% of the control value at 14 days after treatment. Further, its curative and systemic effects were not significant even at 100 ¥õe/ml, and KC10017 was not active against the causal fungus, Magnaporthe grisea. However, it inhibited the melanization of appressoria and mycelia in M. grisea. KC10017 is the first oxadiazole compound showing an inhibitory effect on the biosynthesis of melanin in M. grisea. It was further confirmed that the protective activity of KC10017 was counteracted by wound inoculation of M. grisea. These results suggest that a compound with characteristics like KC10017 has potential as a new fungicide for rice blast.
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